Gut microbiota dysbiosis is central to UC pathogenesis, providing a rationale for probiotic-based, microbiota-targeted interventions
Its primary action is mediated by binding to its specific receptor, IGF1R, which is present on the surface of several cell types in a multitude of tissues
Nerve damage is thought to affect up to half of people with diabetes
For example, collagen peptides identified from broccoli protein hydrolysates, have shown strong binding affinity to ACE through hydrogen bonding, electrostatic interaction, and hydrophobic interaction, thereby reducing vascular constriction and lowering blood pressure [131]
AGEs, in turn, generate ROS through various mechanisms, including metal-catalyzed oxidation reactions