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Key Preclinical Study (Neelakantan et al., 2018): Treatment in diet-induced obese mice produced progressive body weight loss, reduced white adipose tissue mass and adipocyte size, decreased total cholesterol, and no changes in food intake effects were metabolic, not appetite-driven

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Mansurov, A

Ghrelin also acts through a GPCR but in this case the activation of this receptor leads to the stimulation of the activity of phospholipase C (PLC) that induces the formation of inositol 1,4,5-triphosphate (IP3), and diacylglycerol (DAG) ( Figure 5 )