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With its localization on the presynaptic membrane of dopaminergic nerve terminals [17, 18], DAT utilizes the Na + gradient created by the plasma membrane Na + /K + ATPase as the driving force to transport synaptic dopamine across cellular membrane [19, 20]

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In some embodiments, an otic composition or formulation disclosed herein comprises less than about 25 ppm of each of C1-C4 alcohols or C1-C4 glycols