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The potential effects of melatonin as an anticancer agent with multimodal oncostatic action have been reported [22] , showing its ability to reduce tumor progression in monotherapy or combination with other treatments [28]

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Hsp90 is critical for eNOS activity, and is involved in a reciprocal interactive relationship with eNOS and CaM : Hsp90 enhances both the magnitude and sensitivity of eNOS activation in response to Ca 2+ -CaM