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Inflammation, free radical damage, oxidative stress and cancer

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Resveratrol stimulates SIRT1, upregulating PPAR- and its downstream fatty acid oxidation genes, thereby enhancing hepatic lipogenesis and elevating circulating IGF-1 levels ( Generally, resveratrol suppresses adipogenesis through inhibition of C/EBP, downregulates C/EBP and PPAR- expressionkey drivers of fibroblast-to-adipocyte morphological transitionand enhances IGF-1 signaling pathway activation