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This trend has clearly been evident in the patent literature (Table 2)

The molecule was developed by the Australian pharmaceutical company Metabolic Pharmaceuticals (in collaboration with Monash University) and advanced through Phase I safety trials and a Phase IIb obesity efficacy trial enrolling approximately 900 participants in total

Radiesse delivers facial enhancement for as long as eighteen to twenty-four months

The head-by-head comparison between the three interventions was made only in one paper of the included studies