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Interestingly, in a rat model of lysolecithin demyelination, M2 depletion was associated with delayed oligodendrocyte differentiation and nodal reconstruction (Miron et al., 2013) suggesting the pro-myelinating role of M2 macrophages

[3] In humans, defects in GSS are inherited in an autosomal recessive way and are the cause of severe metabolic acidosis, 5-oxoprolinuria, increased rate of haemolysis, and defective function of the central nervous system

SP increased the expression of granzyme B in CD8 + cells through the neurokinin-1 receptor (NK-1R) in a C3H/HeJ mouse model for AA [102]

However, both experimental studies and randomized clinical trial studies are needed to evaluate the efficacy of biotin supplementation in migraine patients