Glutathione synthesis and maintenance require coordinated metabolic inputs, including NADPH generated through the pentose phosphate pathway, and are transcriptionally regulated by nuclear factor erythroid 2-related factor 2 (NRF2) (2224)
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The thioredoxin (Trx) and glutaredoxin (Grx) systems are important as antioxidants for maintaining cellular redox balance and providing electrons for thiol-dependent reactions like those catalyzed by ribonucleotide reductase and peroxiredoxins (Prxs)
2021, Khan et al
