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Cyclooxygenase 2 COX-2, also known as cyclooxygenase 2 or prostaglandin-endoperoxide synthase 2, is an enzyme that plays a key role in the biosynthesis of prostanoids, which include prostaglandins, prostacyclins, and thromboxanes

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It is also used to treat pernicious anemia, vitamin B 12 deficiency (due to low intake from food or inability to absorb due to genetic or other factors), thyrotoxicosis, hemorrhage, malignancy, liver disease and kidney disease