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Adequate B12 levels reduce the risk of neural tube defects like spina bifida and anencephaly, while B12 deficiency increases the risk by up to three times

[1] Because intrinsic-factor-dependent uptake in the distal ileum can be absent in conditions such as autoimmune gastritis, pancreatic insufficiency, or bariatric surgery, the intramuscular or subcutaneous route bypasses gastrointestinal barriers and reliably restores serum concentrations

TPE has been used as part of treatment plans for Alzheimers disease, inflammatory conditions, chronic viral infections, kidney issues, and more by reducing the protein and harmful components in the body