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In recent years, an increasing number of researchers have analyzed the close relationship between gut microbiota and human physiology and pathology from various perspectives, such as the brain-gut axis, liver-gut axis, and lung-gut axis

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Literature data supported the potential role of mitochondrial dysfunctions (i.e., altered ATP production) in the onset of CFS symptoms such as fatigue and post exertional malaise (Morris and Maes 2014)

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