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Riboflavin seems to function as a proteasome inhibitor 43,45 , resulting in the decreased degradation of the NF-B inhibitor, phosphorylated-inhibitor kappa (P-IB), thus preventing nuclear translocation of NF-B and subsequent pro-inflammatory gene activation 46

A desensitization procedure might be suggested by the doctor if the individual requires a certain drug and there is no other sulfa-free alternative

10.1016/j.advnut.2023.07.006 213 ShangC.LiuZ.ZhuY.LuJ.GeC.ZhangC.et al (2021)

When theres a decrease of NAD+ in the body, this negatively affects mitochondrial health because theyre not able to repair the damage as well

Immune system modulation : Enhancing or suppressing immune responses