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Park et al., 2010b), shown in Figure 5D

Several limitations should also be highlighted, such as the lack of knowledge of the age, sex and health status of the subjects included in this study

While GHRP-6 activates GHS-R1a broadly across multiple tissue types with varying downstream consequences, ipamorelin's interaction with the receptor appears to favor the conformational state that drives somatotroph GH release without efficiently engaging the receptor conformations responsible for appetite stimulation or ACTH release

Rodriguez, 2009