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Here is what matters: aim the needle at the glass wall of the vial, not directly at the lyophilized powder cake at the bottom

In further course, isoprenaline challenge(s) resulted in uniform severe myocardial lesions presentation (Figure 10, Figure 11, Figure 12, Figure 13, Figure 14, Figure 15, Figure 16, Figure 17, Figure 18 and Figure 19, Table 2, Table 3 and Table 4)