methionine glutathione Vitamin B12 is the essential cofactor that lets the Folate Cycle hand a methyl group to homocysteine (via synthase), enabling methionine → SAMe production; SAMe is the cell's universal methyl donor quality ingredients. Methionine metabolism to glutathione [48,49].
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![methionine glutathione Vitamin B12 is the essential cofactor that lets the Folate Cycle hand a methyl group to homocysteine (via synthase), enabling methionine SAMe production; SAMe is the cell's universal methyl donor quality ingredients. Methionine metabolism to glutathione [48,49].](https://ars.els-cdn.com/content/image/1-s2.0-S0891584916001271-gr2.jpg)
![methionine glutathione Vitamin B12 is the essential cofactor that lets the Folate Cycle hand a methyl group to homocysteine (via synthase), enabling methionine SAMe production; SAMe is the cell's universal methyl donor quality ingredients. Methionine metabolism to glutathione [48,49].](https://cdn.shopify.com/s/files/1/1283/2557/files/Methionine_1024x1024.jpg?v=1672896762)
![methionine glutathione Vitamin B12 is the essential cofactor that lets the Folate Cycle hand a methyl group to homocysteine (via synthase), enabling methionine SAMe production; SAMe is the cell's universal methyl donor quality ingredients. Methionine metabolism to glutathione [48,49].](https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fs41392-020-00349-7/MediaObjects/41392_2020_349_Fig1_HTML.png)
![methionine glutathione Vitamin B12 is the essential cofactor that lets the Folate Cycle hand a methyl group to homocysteine (via synthase), enabling methionine SAMe production; SAMe is the cell's universal methyl donor quality ingredients. Methionine metabolism to glutathione [48,49].](https://www.mdpi.com/ijms/ijms-24-08044/article_deploy/html/images/ijms-24-08044-g001-550.jpg)