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A high GSH concentration and a reduced cellular state are known to promote self-renewal, allowing the GSH-to-ROS ratio to be a key determinant of cell fate (Ji et al., 2010

Every cell in your body relies on glutathione, whether it be to maintain the health of your skin and hair, prevent nerve damage, or fight germs

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As a result, the production of a broad array of critical antioxidants, including glutathione, is severely limited and leaves the macrophage susceptible to the oxidative stress that accompanies acute insults