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Funder Information Declared Abbreviations ALDH2 aldehyde dehydrogenase 2 WT wild type MDA malondialdehyde 4-HNE 4-hydroxy-trans-2-nonenal AA allyl alcohol GSH glutathione ROS reactive oxygen species GPX4 glutathione peroxidase 4 KI knock-in PLP periodate-lysine-paraformaldehyde -H2AX phosphorylated-histone H2AX HMGB1 high mobility group box protein 1 TUNEL terminal deoxynucleotidyl transferase dUTP nick end labeling HPLC high performance liquid chromatography SDS Sodium dodecyl sulfate ADH5 alcohol dehydrogenase 5 GCLC glutamate-cysteine ligase catalytic subunit xCT cystine transporter solute carrier family 7 member 11/xCT TFR1 transferrin receptor 1 GSSG glutathione disulfide TBARS thiobarbituric acid reactive substances ALT alanine aminotransferase References [1]. [2]. [3]. [4]. [5]. [6]. [7]. [8]. [9]. [10]. [11]. [12]. [13]. [14]. [15]

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