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Liver glyoxalase cycle enzymes, glyoxalase 1 (GLO1) and hydroxyacylglutathione hydrolase (GLO2), were comparable between genotypes on both diets (Fig

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There was a final assessment 24 hr after surgery

Combined with the above research results, we can use these substances regulating oxidative stress as potential therapeutic drugs for KOA and verify the ability of these substances to regulate ROS in the pathogenesis of KOA in animal experiments

These findings suggest that topiramate may exert dual effects on oxidative stress, offering neuroprotection in certain contexts while exacerbating oxidative stress under different conditions and dosages