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Remember, medical oversight is not just a formality

Determination of melanin content The total concentration of melanin produced by the treated cells was calculated as a previously reported method by Tsuboi et al

doi: 10.1016/j.cellsig.2025.111674 32 LiuKWangLLouZGuoLXuYQiHet al

In turn, melatonin reduces estrogen concentration by inhibiting the binding of the E2-ER complex to the estrogen response element (ERE) in DNA [52,53]