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It is not intended as a standalone therapeutic dose for severe B12 deficiency, which would require separate supplementation at different intervals and doses under veterinary guidance

In contrast to the class Ia diferric tyrosyl radical (Fe III 2 -Y) cofactor, which can self-assemble and mature from Fe II 2 -NrdF and molecular O 2 , generation of the Mn III 2 -Y cofactor in the class Ib enzyme requires the reduced form of a flavoprotein, NrdI hq , and O 2 to create superoxide anion for active site assembly and oxidative maturation

The study itself is really bad

They have been extensively studied in large-scale human clinical trials, with robust safety data spanning over a decade