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In particular, when used in conjunction with immune checkpoint inhibitors (ICIs) and Stimulator of Interferon Genes (STING) agonists, lactate inhibitors can significantly decrease tumor immunosuppression and promote the activation of tumor-infiltrating T cells [228, 229]

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Additionally, the long-term consequences of endothelial IGF- 1R deficiency on skeletal muscle function should be explored, as chronic vascular insufficiency could eventually contribute to muscle wasting and frailty