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Their dysfunction is closely associated with neurodevelopmental disorders such as autism and schizophrenia ( The ventral pallidum (VP) receives GABAergic inputs from the nucleus accumbens and projects to the mediodorsal thalamic nucleus and prefrontal cortex, forming the cortex-striatum-cortex loop, which regulates motivated behavior and reward evaluation ( Evidence from single-cell transcriptomics indicates that in VIP interneurons of ASD patients brains, transcription factors such as Abelson Helper Integration Site 1 (AHI1) and synaptic genes like RAS-Associated Protein RAB3A (RAB3A) are downregulated