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doi: 10.1111/MICC.12718 38 ZhangQ.JuY.MaY.WangT

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Primarily, these cells express very low levels of key antioxidant enzymes, including catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD), which are primary defense mechanisms against reactive oxygen species (ROS) [81]

Although in vitro cell culture studies and in vivo studies using animal models suggest that Se is effective for cancer prevention, the inconsistent results obtained in Se clinical trials indicate that a more focused approach to understand the mechanisms of different forms of Se on antioxidant and anticancer activity is needed