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usually most pronounced during dose escalation Diarrhea : Affects 12-17% of patients, typically mild to moderate in severity Vomiting : Reported in 6-10% of patients, more common at higher doses Constipation : Occurs in 6-11% of patients Abdominal pain and dyspepsia : Generally transient Decreased appetite : An expected pharmacological effect contributing to weight loss Other documented adverse effects include injection site reactions, hypoglycemia (when used with insulin or sulfonylureas), and less commonly, fatigue

It is found in high concentrations in your muscles and circulates in your blood to various organs that need it

Additionally, while some may tolerate a high amount of caffeine, many will experience side effects, including hormone changes and sleep disturbance

A serotonin dose response (0.01-10 M) was determined for each strip with the mucosa intact or denuded