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Five different PPIs are approved for the treatment of GERD, including: omeprazole (Prilosec, Dexilant) lansoprazole (Prevacid) rabeprazole (Aciphex) pantoprazole (Protonix) esomeprazole (Nexium) dexlansoprazole (Dexilant) A sixth PPI product consists of a combination of omeprazole and sodium bicarbonate (Zegerid)