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Alterations in the composition of the gut microbiome, a condition known as gut dysbiosis, have been strongly associated with a range of diseases, including inflammatory bowel disease (IBD), metabolic syndrome, and various cancers

The precursors of ceramides (sphingomyelin, glucosylceramides) were also unaffected by long-term smoking although an increasing trend in the content of phospholipids (average increase of 58%) in smokers compared to non-smokers was observed

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