Zhang J, Fan J, Venneti S, Cross JR, Takagi T, Bhinder B, Djaballah H, Kanai M, Cheng EH, Judkins AR, Pawel B, Baggs J, Cherry S, Rabinowitz JD, Thompson CB
Another common preclinical model involves using chemically induced damage, such as oxidative stress or inflammation, to test the peptides potential in mitigating cellular damage
850 The metabolic regulator sestrin 2 alleviates ferroptosis caused by intestinal I/R injury by activating the Keap1/Nrf2 signaling pathway
A modern alternative to antibiotics includes phage therapy and anti-colonization strategies, which provide selective suppression of metabolically unfavorable taxa without significantly disrupting the overall microbiota structure
Regulatory approval status Cagrilintide is not currently FDA-approved as a standalone medication