Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription: Synergistic activation of Nrf2 by CBP
At greater than or equal to 4 times the human clinical exposure based on AUC in patients with ITP at 75 mg/day and 2 times the human clinical exposure based on AUC in patients with chronic hepatitis C at 100 mg/day, cataracts were observed in mice after 13 weeks and in rats after 39 weeks of dosing [see Warnings and Precautions (5.5)]
Dosage Pdiatrique La posologie recommande pour les enfants peut varier en fonction de diffrentes conditions mdicales : Pour le traitement initial de l'anmie pernicieuse, la dose habituelle est de 30-50 mcg SC/IM, administre chaque jour pendant 2 semaines, suivie d'un traitement de maintien
Cng dng dng trng, tr thm, kh mi cng nhanh chng v t hiu qu tt hn
Activation of gamma-globin expression by hypoxia-inducible factor 1alpha