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[75] to synergically inhibit the HIF-1/NF-B cascade and regulate ROS clearance and macrophage repolarization in RA combination therapy

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However, the levels of other metabolites such as 5-Aminolevulinate, cysteate, putrescine, 4-Aminobutyraldehyde, kynurenine, serotonin, Formyl-5-hydroxykynurenamine, 5-Hydroxykynurenine, 2-Aminomuconate, xanthine, and 5-Aminolevulinate were significantly increased in LC patients ( Figure 3C , Supplementary Figure 3A )

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