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This diagnostic odyssey exacts a substantial toll on patients, healthcare systems, and society

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Research in this area often investigates peptides that modulate GH pulsatility or directly mimic IGF-1 signaling

740 Activity assays reveal that as expected, Zn II binding to site 2 inhibits turnover by QueD2, which suggests that the active site 1 may well be conformationally plastic or dynamically heterogeneous and must fold to accommodate substrate, in striking contrast to the housekeeping enzyme QueD