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First isolated from cerebral venous blood during slow-wave sleep, DSIP has been studied for its neuromodulatory properties and role in sleep architecture

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After extensive testing of various fragments, they identified a 15-amino acid sequence that exhibited the most potent protective and healing properties

At a molecular level, MET cKO mice showed altered glutamate receptor expression profiles in the hippocampus at P14, including increased GluA1, GluN2A, and decreased GluN2B at the synaptic sites