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Diets with higher protein should be based on more excellent fat, less meal weight, and a better metabolism effect from sugar than the ones with carbohydrates [114]

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Recent imaging studies reveal that BBB breakdown and glymphatic system impairment associated with gliosis occur early in aging, particularly in the hippocampus, and are exacerbated in mild cognitive impairment, correlating with pericyte injury (Montagne et al., 2015)

Importantly, the low translation rate of animal models of BM to human trials has historically been a major obstacle in developing effective therapies [123]