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At higher concentrations, cocaine also blocks different voltage gated channels in a state-dependent manner with a higher affinity for inactivated and open states vs rested/closed states of the channels

[9] The World Health Organization estimates that, annually, more than 7 million people die from tobacco-related causes, including 1 } : CS1 maint: DOI inactive as of July 2026 (link) Endocrine

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