The Synergistic THC Effect : Biologically, smoking tobacco and cannabis together increases the human bodys absorption of delta-9-tetrahydrocannabinol (THC), the primary psychoactive component of cannabis, potentially altering brain chemistry more intensely than cannabis alone
Neuropsychopharmacology (2008) 33:48090
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However, in the SZ population, this pattern of desensitization and resensitization may have a different presentation due to the decreased expression of nicotinic receptors, which may account for their increased severity of tobacco addiction (108)