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The MPP+ is then released into the extracellular space and subsequently absorbed into dopaminergic neurons and terminals by dopaminergic transporters for which it shows high affinity (Cui et al., 2017)

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However, other studies have shown that the I923V variant does not affect dsRNA binding activity but still exhibits reduced biological activity, suggesting an alternative signaling process (108)

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Notably, the combination of AOD9604 and HA appeared to offer greater benefits than either agent alone, suggesting a synergistic effect in promoting cartilage protection and repair [1]