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In controlled studies on aged skin, GHK-Cu tightened skin, improved elasticity and firmness, and reduced fine lines, wrinkles and photodamage

Later, the PTWI was amended to a tolerable monthly intake (TMI) of 25 g per kg body weight per month (0.83 g per kg body weight per day), and E Cd /E cr of 5.24 g/g creatinine was assigned as a threshold level [4]