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Endoplasmic reticulum stress in disease pathogenesis

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Studies have demonstrated that lactate-induced autophagy activation can dictate cellular fate between survival and ferroptotic death based on the iron-handling capacity and antioxidant reserve of specific cell types (101,119,148)

Attention is also paid to the effect of antioxidants to alleviate the level of oxidative stress, which is a common denominator of various chronic diseases such as neurological disorders, cancer, cardiovascular, renal, lung, metabolic, neurological, psychiatric, and other diseases