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In summary, the particle size appears to be a critical factor influencing the biological response of blood and immune cells to PET exposure, with NPs ( 200 nm) generally exhibiting higher toxicity compared to larger MPs

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10.1016/j.bioorg.2021.105329 193 MartinelloM.MutinelliF

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These overall immunological responses contribute to the enlargement and overgrowth of the synovial lining, destruction of cartilage, formation of osteoclasts, synovial inflammation, pain, and an elevated risk of neoplastic infections [12]

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"Perspective: Practical Approach to Preventing Subclinical B12 Deficiency in Elderly Population"

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