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Meanwhile, NNMTi preserves lean body mass: it reduces fat accumulation without causing muscle loss, which is crucial for maintaining basal metabolism and preventing weight regain after dieting.These in vivo findings fully validate the efficacy and safety of NNMTi in obesity intervention, laying a solid foundation for its subsequent clinical research and drug development

Additional risk factors include advancing age (due to reduced gastric acid production), excessive alcohol consumption (impairing absorption and storage), and rare genetic disorders affecting B12 transport or metabolism

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Both effects operate through pathways that appear independent of the canonical growth hormone receptor