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This causes mitochondrial membrane depolarization, mitochondrial permeability transition pore (mPTP) opening, and dysfunction

Cuproptosis is a relatively recently described form of cell death caused by copper accumulation in mitochondria, which impairs mitochondrial respiration and protein lipidation, leading to membrane permeability, cell damage, and the initiation of apoptosis pathways under various conditions [35,36,37,38]

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