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A central objective of pro-oxidant therapeutic strategies is to trigger ferroptosis a distinct, iron-dependent form of regulated cell death characterized by excessive lipid peroxidation

The antioxidant properties of carotenoids are related to conjugated double bonds which can accommodate unpaired electrons and extensively delocalize them over the conjugated system of double bonds (Mortensen et al

Because mitochondria utilize about 90% of inhaled oxygen, they are highly vulnerable to free radical oxidative damage

In the neurogenic niche, astrocytes express ciliary neurotrophic factor (CNTF), while the receptor, CNTFR, is predominantly expressed in neural progenitor cells and hippocampal neurons [22]

Depression and other common mental disorders: global health estimates