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The main physical barrier between the blood and the CNS is composed of the BBB endothelial cells (BECs) of the blood vessels ( Figure 1 BBB Endothelial Cells BECs constitute the innermost luminal component of the BBB ( Junctional Complex The junctional complex is compromised by tight junctions (TJs), adherens junctions (AJs), and GAP junctions (GJs) (Figure 1

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