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Consequently, impaired ketogenesis and production of BHB in COVID-19 ARDS may be at the root of the metabolic dysregulation and defective effector function of T cells, and may predispose patients to pulmonary pathology, including fibrosis

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Novel oxicam analogs, particularly those with an arylpiperazine moiety at the thiazine ring, have shown greater efficacy in downregulating DDAHs and PRMTs and upregulating ARG2 compared to traditional oxicams such as piroxicam and meloxicam (157, 158)

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