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First, the complex appears to act as a copper transporter, delivering ionic copper to cutaneous cells where it may activate copper-dependent enzymes involved in extracellular-matrix remodeling and angiogenesis

Cyclic analogues (MT-II) have a wide range of peripheral effects and systemic control is always going to pose an issue in clinical use

The misconception may arise from the higher suicide rate in the age group that most commonly takes isotretinoin, as well as the potential impact of acne on mood and social interactions, which can contribute to depression