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Increases in resting heart rate are a recognised class effect of incretin-based therapies and have been reported with GLP-1 receptor agonists more broadly, as reflected in the Summary of Product Characteristics (SmPC) for licensed agents such as semaglutide (Wegovy) and liraglutide (Saxenda)

A reader is best served by holding two things at once: the mechanism is genuinely interesting, and the human evidence does not yet exist

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In addition to this, vitamin B12 deficiency in the elderly has been associated with many health problems like elevated blood levels of homocysteine that could increase their chances of developing heart disease, stroke, and Alzheimer's disease