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CRN02481 prevented fasting hypoglycaemia and amino acid-stimulated insulin secretion in a Sur1 -/- mouse model of CHI (63)

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Secondary endpoints in trials include reductions in waist circumference , visceral fat mass, appetite scores, and daily caloric intake

This is consistent with the previous findings that hypoxia-response genes were upregulated in the islets of diabetic, but not prediabetic, db/db mice in an inverse relationship with unfolded protein response gene expression 28,33