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1 Introduction Chronic obstructive pulmonary disease (COPD) is a progressive inflammatory disorder with a global prevalence of 10.3% and an estimated 392 million patients worldwide ( Cigarette smoking is the major risk factor for COPD in the Western world ( The lung harbors different subsets of macrophages, including interstitial macrophages that are present in the lung interstitium between blood vessels and alveoli whereas alveolar macrophages (AM) are found in the alveolar space and airspace ( Single-cell genomics technologies, particularly single-cell RNA-sequencing (scRNA-seq), now allows a detailed characterization of such complex cell communities and their molecular mechanisms

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She remembers seeing a bomber plane coming over really really low one day and crashing not far from where she lived and described it as very frightening. Margaret later went on to join the Womens Auxiliary Air Force (WAAF), established in 1939, when she was around 18