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In fact, the AHA considers smoking to be the most important risk factor for preventable heart disease among men and women

Nicotine increases energy metabolism and decreases the efficacy of energy conversion [245]

Can J Psychiatry (2009) 54:36878

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Further investigations are warranted to understand the exact mechanisms responsible for smoking-mediated immunopathology and to answer lingering questions over why cigarette smoking is always harmful rather than beneficial even though it exerts dual effects on immune responses