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Identification and characterization of Al + induced anion channels

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Ferritin, an essential iron-storage protein, chelates free iron into Fe 3+ to prevent the Fenton reaction

Both exogenous and endogenous antioxidants can manipulate the ROS levels, by regulating gene expression and signaling pathways, and eventually maintain the oxidative balance and the integrity of cellular components (24, 121)

Ferroptotic macrophages can trigger a systemic inflammatory response by releasing DAMPs and pro-inflammatory cytokines that can activate the inflammasome