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Reviews of the rodent work note that the mechanism doesnt involve the hormonal suppression or receptor desensitization that would predict tolerance or rebound, and that adipose SAM levels tend to normalize rather than crash under inhibition

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Distribution: Transcobalamin II appears to be involved in the rapid transport of the cobalamin to tissues

Health Canada has not evaluated these compounds for safety or efficacy in treating any medical condition

Some people report a temporary sensation of pressure or flushing if lipotropic therapy is administered too quickly